Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson’s disease-linked DNAJC6 mutations

Loss-of-function mutations of DNAJC6, encoding HSP40 auxilin, have recently been identified in patients with early-onset Parkinson’s disease (PD). To study the roles of DNAJC6 in PD pathogenesis, we used human embryonic stem cells with CRISPR-Cas9–mediated gene editing. Here, we show that DNAJC6 mut...

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Dades bibliogràfiques
Publicat a:Sci Adv
Autors principals: Wulansari, Noviana, Darsono, Wahyu Handoko Wibowo, Woo, Hye-Ji, Chang, Mi-Yoon, Kim, Jinil, Bae, Eun-Jin, Sun, Woong, Lee, Ju-Hyun, Cho, Il-Joo, Shin, Hyogeun, Lee, Seung-Jae, Lee, Sang-Hun
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2021
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888924/
https://ncbi.nlm.nih.gov/pubmed/33597231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb1540
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