Vaccine Efficacy of ALVAC-HIV and Bivalent Subtype C gp120/MF59 in Adults

BACKGROUND: A safe, effective vaccine is essential to end HIV. A canarypox/protein HIV vaccine regimen showed modest efficacy at reducing infection in Thailand. An analogous regimen using HIV-1 subtype C virus demonstrated potent humoral and cellular responses in a Phase 1/2a trial and triggered a P...

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Published in:N Engl J Med
Main Authors: Gray, Glenda E, Bekker, Linda-Gail, Laher, Fatima, Malahleha, Mookho, Allen, Mary, Moodie, Zoe, Grunenberg, Nicole, Huang, Yunda, Grove, Doug, Prigmore, Brittany, Kee, Jia J., Benkeser, David, Hural, John, Innes, Craig, Lazarus, Erica, Meintjes, Graeme, Naicker, Nivashnee, Kalonji, Dishiki, Nchabeleng, Maphoshane, Sebe, Modulakgotla, Singh, Nishanta, Kotze, Philip, Kassim, Sheetal, Dubula, Thozama, Naicker, Vimla, Brumskine, William, Ncayiya, Cleon N, Ward, Amy M, Garrett, Nigel, Kistnasami, Girisha, Gaffoor, Zakir, Selepe, Pearl, Makhoba, Philisiwe B, Mathebula, Matsontso P, Mda, Pamela, Adonis, Tania, Mapetla, Katlego S, Modibedi, Bontle, Philip, Tricia, Kobane, Gladys, Bentley, Carter, Ramirez, Shelly, Takuva, Simbarashe, Jones, Megan, Sikhosana, Mpho, Atujuna, Millicent, Andrasik, Michele, Hejazi, Nima S., Puren, Adrian, Wiesner, Lubbe, Phogat, Sanjay, Diaz Granados, Carlos, Koutsoukos, Marguerite, Van Der Meeren, Olivier, Barnett, Susan W., Kanesa-thasan, Niranjan, Kublin, James G., McElrath, M. Juliana, Gilbert, Peter B., Janes, Holly, Corey, Lawrence
Format: Artigo
Language:Inglês
Published: Massachusetts Medical Society 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888373/
https://ncbi.nlm.nih.gov/pubmed/33761206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa2031499
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