Vaccine Efficacy of ALVAC-HIV and Bivalent Subtype C gp120/MF59 in Adults

BACKGROUND: A safe, effective vaccine is essential to end HIV. A canarypox/protein HIV vaccine regimen showed modest efficacy at reducing infection in Thailand. An analogous regimen using HIV-1 subtype C virus demonstrated potent humoral and cellular responses in a Phase 1/2a trial and triggered a P...

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Publicado no:N Engl J Med
Main Authors: Gray, Glenda E, Bekker, Linda-Gail, Laher, Fatima, Malahleha, Mookho, Allen, Mary, Moodie, Zoe, Grunenberg, Nicole, Huang, Yunda, Grove, Doug, Prigmore, Brittany, Kee, Jia J., Benkeser, David, Hural, John, Innes, Craig, Lazarus, Erica, Meintjes, Graeme, Naicker, Nivashnee, Kalonji, Dishiki, Nchabeleng, Maphoshane, Sebe, Modulakgotla, Singh, Nishanta, Kotze, Philip, Kassim, Sheetal, Dubula, Thozama, Naicker, Vimla, Brumskine, William, Ncayiya, Cleon N, Ward, Amy M, Garrett, Nigel, Kistnasami, Girisha, Gaffoor, Zakir, Selepe, Pearl, Makhoba, Philisiwe B, Mathebula, Matsontso P, Mda, Pamela, Adonis, Tania, Mapetla, Katlego S, Modibedi, Bontle, Philip, Tricia, Kobane, Gladys, Bentley, Carter, Ramirez, Shelly, Takuva, Simbarashe, Jones, Megan, Sikhosana, Mpho, Atujuna, Millicent, Andrasik, Michele, Hejazi, Nima S., Puren, Adrian, Wiesner, Lubbe, Phogat, Sanjay, Diaz Granados, Carlos, Koutsoukos, Marguerite, Van Der Meeren, Olivier, Barnett, Susan W., Kanesa-thasan, Niranjan, Kublin, James G., McElrath, M. Juliana, Gilbert, Peter B., Janes, Holly, Corey, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: Massachusetts Medical Society 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888373/
https://ncbi.nlm.nih.gov/pubmed/33761206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa2031499
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