Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and Therapy

Most human cancers converge to a deregulated methylome with reduced global levels and elevated methylation at select CpG islands. To investigate the emergence and dynamics of the cancer methylome, we characterized genome-wide DNA methylation in preneoplastic monoclonal B-cell lymphocytosis (MBL) and...

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Bibliografiske detaljer
Udgivet i:Blood Cancer Discov
Main Authors: Kretzmer, Helene, Biran, Anat, Purroy, Noelia, Lemvigh, Camilla K., Clement, Kendell, Gruber, Michaela, Gu, Hongcang, Rassenti, Laura, Mohammad, Arman W., Lesnick, Connie, Slager, Susan L., Braggio, Esteban, Shanafelt, Tait D., Kay, Neil E., Fernandes, Stacey M., Brown, Jennifer R., Wang, Lili, Li, Shuqiang, Livak, Kenneth J., Neuberg, Donna S., Klages, Sven, Timmermann, Bernd, Kipps, Thomas J., Campo, Elias, Gnirke, Andreas, Wu, Catherine J., Meissner, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: American Association for Cancer Research 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888194/
https://ncbi.nlm.nih.gov/pubmed/33604581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2643-3230.BCD-19-0058
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