RAD6B Loss Disrupts Expression of Melanoma Phenotype in Part by Inhibiting WNT/β-Catenin Signaling

Canonical Wnt signaling is critical for melanocyte lineage commitment and melanoma development. RAD6B, a ubiquitin-conjugating enzyme critical for translesion DNA synthesis, potentiates β-catenin stability/activity by inducing proteasome-insensitive polyubiquitination. RAD6B expression is induced by...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Am J Pathol
Huvudupphovsmän: Sarma, Ashapurna, Gajan, Ambikai, Kim, Seongho, Gurdziel, Katherine, Mao, Guangzhao, Nangia-Makker, Pratima, Shekhar, Malathy P.V.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Investigative Pathology 2021
Ämnen:
Regular Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888193/
https://ncbi.nlm.nih.gov/pubmed/33181138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2020.10.015
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk