Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor

[Image: see text] Despite being among the most characterized G protein-coupled receptors (GPCRs), adenosine receptors (ARs) have always been a difficult target in drug design. To date, no agonist other than the natural effector and the diagnostic regadenoson has been approved for human use. Recently...

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Bibliografiske detaljer
Udgivet i:ACS Pharmacol Transl Sci
Main Authors: Deganutti, Giuseppe, Barkan, Kerry, Preti, Barbara, Leuenberger, Michele, Wall, Mark, Frenguelli, Bruno G., Lochner, Martin, Ladds, Graham, Reynolds, Christopher A.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2021
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887845/
https://ncbi.nlm.nih.gov/pubmed/33615181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00195
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