Asymmetric opening of the homopentameric 5-HT(3A) serotonin receptor in lipid bilayers

Pentameric ligand-gated ion channels (pLGICs) of the Cys-loop receptor family are key players in fast signal transduction throughout the nervous system. They have been shown to be modulated by the lipid environment, however the underlying mechanism is not well understood. We report three structures...

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Udgivet i:Nat Commun
Main Authors: Zhang, Yingyi, Dijkman, Patricia M., Zou, Rongfeng, Zandl-Lang, Martina, Sanchez, Ricardo M., Eckhardt-Strelau, Luise, Köfeler, Harald, Vogel, Horst, Yuan, Shuguang, Kudryashev, Mikhail
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887223/
https://ncbi.nlm.nih.gov/pubmed/33594077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21016-7
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