ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism

Recurring chromosomal translocation t(10;17)(p15;q21) present in a subset of human acute myeloid leukemia (AML) patients creates an aberrant fusion gene termed ZMYND11-MBTD1 (ZM); however, its function remains undetermined. Here, we show that ZM confers primary murine hematopoietic stem/progenitor c...

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Publicado no:Nat Commun
Main Authors: Li, Jie, Galbo, Phillip M., Gong, Weida, Storey, Aaron J., Tsai, Yi-Hsuan, Yu, Xufen, Ahn, Jeong Hyun, Guo, Yiran, Mackintosh, Samuel G., Edmondson, Ricky D., Byrum, Stephanie D., Farrar, Jason E., He, Shenghui, Cai, Ling, Jin, Jian, Tackett, Alan J., Zheng, Deyou, Wang, Gang Greg
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7886901/
https://ncbi.nlm.nih.gov/pubmed/33594072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21357-3
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