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Using CRISPR to enhance T cell effector function for therapeutic applications

T cells are critical to fight pathogenic microbes and combat malignantly transformed cells in the fight against cancer. To exert their effector function, T cells produce effector molecules, such as the pro-inflammatory cytokines IFN-γ, TNF-α and IL-2. Tumors possess many inhibitory mechanisms that d...

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Bibliografiska uppgifter
I publikationen:Cytokine X
Huvudupphovsman: Freen-van Heeren, Julian J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7885876/
https://ncbi.nlm.nih.gov/pubmed/33604565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cytox.2020.100049
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