Silencing Smad7 potentiates BMP2-induced chondrogenic differentiation and inhibits endochondral ossification in human synovial-derived mesenchymal stromal cells

BACKGROUND: Bone morphogenetic protein 2 (BMP2) is a promising chondrogenic growth factor for cartilage tissue-engineering, but it also induces robust endochondral ossification. Human synovial-derived mesenchymal stromal cells (hSMSCs) have attracted great interest due to their poor potential for di...

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Veröffentlicht in:Stem Cell Res Ther
Hauptverfasser: Xiao, Pengcheng, Zhu, Zhenglin, Du, Chengcheng, Zeng, Yongsheng, Liao, Junyi, Cheng, Qiang, Chen, Hong, Zhao, Chen, Huang, Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7885459/
https://ncbi.nlm.nih.gov/pubmed/33588941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02202-2
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