Palladin isoforms 3 and 4 regulate cancer-associated fibroblast pro-tumor functions in pancreatic ductal adenocarcinoma

Pancreatic Ductal Adenocarcinoma (PDAC) has a five-year survival under 10%. Treatment is compromised due to a fibrotic-like stromal remodeling process, known as desmoplasia, which limits therapeutic perfusion, supports tumor progression, and establishes an immunosuppressive microenvironment. These p...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Alexander, J. I., Vendramini-Costa, D. B., Francescone, R., Luong, T., Franco-Barraza, J., Shah, N., Gardiner, J. C., Nicolas, E., Raghavan, K. S., Cukierman, E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7884442/
https://ncbi.nlm.nih.gov/pubmed/33589694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-82937-3
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