Deciphering the chemical instability of sphaeropsidin A under physiological conditions – degradation studies and structural elucidation of the major metabolite

The fungal metabolite sphaeropsidin A (SphA) has been recognised for its promising cytotoxicity, particularly towards apoptosis- and multidrug-resistant cancers. Owing to its intriguing activity, the development of SphA as a potential anticancer agent has been pursued. However, this endeavour is com...

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Bibliographic Details
Published in:Org Biomol Chem
Main Authors: van der Westhuyzen, Alet E., Ingels, Aude, Rosière, Rémi, Amighi, Karim, Oberer, Lukas, Gustafson, Kirk R., Wang, Dongdong, Evidente, Antonio, Maddau, Lucia, Masi, Marco, de Villiers, André, Green, Ivan R., Berger, Walter, Kornienko, Alexander, Mathieu, Veronique, van Otterlo, Willem A. L.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7881364/
https://ncbi.nlm.nih.gov/pubmed/33016969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0ob01586e
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