Myeloma-specific superenhancers affect genes of biological and clinical relevance in myeloma

Multiple myeloma (MM) is an aggressive plasma cell neoplasm characterized by genomic heterogeneity. Superenhancers (SEs) are defined as large clusters of enhancers in close genomic proximity, which regulate genes for maintaining cellular identity and promote oncogenic transcription to which cancer c...

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Bibliografske podrobnosti
izdano v:Blood Cancer J
Main Authors: Jia, Yunlu, Zhou, Jianbiao, Tan, Tze King, Chung, Tae-Hoon, Wong, Regina Wan Ju, Chooi, Jing-Yuan, Lim, Julia Sze Lynn, Sanda, Takaomi, Ooi, Melissa, De Mel, Sanjay, Soekojo, Cinnie, Chen, Yongxia, Zhang, Enfan, Cai, Zhen, Shen, Peng, Ruan, Jian, Chng, Wee-Joo
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7881003/
https://ncbi.nlm.nih.gov/pubmed/33579893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-021-00421-7
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