Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts

Even distinct cancer types share biological hallmarks. Here, we investigate polygenic risk score (PRS)-specific pleiotropy across 16 cancers in European ancestry individuals from the Genetic Epidemiology Research on Adult Health and Aging cohort (16,012 cases, 50,552 controls) and UK Biobank (48,969...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Graff, Rebecca E., Cavazos, Taylor B., Thai, Khanh K., Kachuri, Linda, Rashkin, Sara R., Hoffman, Joshua D., Alexeeff, Stacey E., Blatchins, Maruta, Meyers, Travis J., Leong, Lancelote, Tai, Caroline G., Emami, Nima C., Corley, Douglas A., Kushi, Lawrence H., Ziv, Elad, Van Den Eeden, Stephen K., Jorgenson, Eric, Hoffmann, Thomas J., Habel, Laurel A., Witte, John S., Sakoda, Lori C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880989/
https://ncbi.nlm.nih.gov/pubmed/33579919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21288-z
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