Extrafollicular CD4 T cell-derived IL-10 functions rapidly and transiently to support anti-Plasmodium humoral immunity

Immunity against malaria depends on germinal center (GC)-derived antibody responses that are orchestrated by T follicular helper (TFH) cells. Emerging data show that the regulatory cytokine IL-10 plays an essential role in promoting GC B cell responses during both experimental malaria and virus infe...

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Pubblicato in:PLoS Pathog
Autori principali: Surette, Fionna A., Guthmiller, Jenna J., Li, Lei, Sturtz, Alexandria J., Vijay, Rahul, Pope, Rosemary L., McClellan, Brandon L., Pack, Angela D., Zander, Ryan A., Shao, Peng, Lan, Linda Yu-Ling, Fernandez-Ruiz, Daniel, Heath, William R., Wilson, Patrick C., Butler, Noah S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880450/
https://ncbi.nlm.nih.gov/pubmed/33529242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009288
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