Anti-epileptic drug topiramate upregulates TGFβ1 and SOX9 expression in primary embryonic palatal mesenchyme cells: Implications for teratogenicity

Topiramate is an anti-epileptic drug that is commonly prescribed not just to prevent seizures but also migraine headaches, with over 8 million prescriptions dispensed annually. Topiramate use during pregnancy has been linked to significantly increased risk of babies born with orofacial clefts (OFCs)...

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Foilsithe in:PLoS One
Main Authors: Rafi, Syed K., Goering, Jeremy P., Olm-Shipman, Adam J., Hipp, Lauren A., Ernst, Nicholas J., Wilson, Nathan R., Hall, Everett G., Gunewardena, Sumedha, Saadi, Irfan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2021
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880431/
https://ncbi.nlm.nih.gov/pubmed/33577554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0246989
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