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Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis

We previously reported that Tangshen formula (TSF), a Chinese herbal medicine for diabetic kidney disease (DKD) therapy, imparts renal protective effects. However, the underlying mechanisms of these effects remain unclear. Pyroptosis is a form of programmed cell death that can be triggered by the NL...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Li, Nan, Zhao, Tingting, Cao, Yongtong, Zhang, Haojun, Peng, Liang, Wang, Yan, Zhou, Xuefeng, Wang, Qian, Li, Jialin, Yan, Meihua, Dong, Xi, Zhao, Hailing, Li, Ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880163/
https://ncbi.nlm.nih.gov/pubmed/33584307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.623489
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