Epithelial TLR4 signaling activates DUOX2 to induce microbiota-driven tumorigenesis

BACKGROUND & AIMS: Chronic colonic inflammation leads to dysplasia and cancer in patients with inflammatory bowel disease (IBD). We have described the critical role of innate immune signaling via toll-like receptor 4 (TLR4) in the pathogenesis of dysplasia and cancer. In the current study, we in...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Burgueño, Juan F, Fritsch, Julia, Gonzalez, Eddy E, Landau, Kevin S, Santander, Ana M, Fernández, Irina, Hazime, Hajar, Davies, Julie M, Santaolalla, Rebeca, Phillips, Matthew C, Diaz, Sophia, Dheer, Rishu, Brito, Nivis, Pignac-Kobinger, Judith, Fernández, Ester, Conner, Gregory E, Abreu, Maria T
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7879481/
https://ncbi.nlm.nih.gov/pubmed/33127391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.10.031
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