Rituximab and obinutuzumab differentially hijack the B cell receptor and NOTCH1 signaling pathways

The anti-CD20 monoclonal antibodies rituximab and obinutuzumab differ in their mechanisms of action, with obinutuzumab evoking greater direct B cell death. To characterize the signaling processes responsible for improved B cell killing by obinutuzumab, we undertook a phosphoproteomics approach and d...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Edelmann, Jennifer, Dokal, Arran D., Vilventhraraja, Emma, Holzmann, Karlheinz, Britton, David, Klymenko, Tetyana, Döhner, Hartmut, Cragg, Mark, Braun, Andrejs, Cutillas, Pedro, Gribben, John G.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878992/
https://ncbi.nlm.nih.gov/pubmed/33615197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102089
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