Identification of SRSF10 as a regulator of SMN2 ISS-N1

Understanding the splicing code can be challenging as several splicing factors bind to many splicing-regulatory elements. The SMN silencer element ISS-N1 is the target of the antisense-oligonucleotide drug Spinraza, which is the treatment against Spinal Muscular Atrophy. However, limited knowledge a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hum Mutat
Prif Awduron: Frederiksen, Sabrina Brøner, Holm, Lise Lolle, Larsen, Martin R., Doktor, Thomas K., Andersen, Henriette S., Hastings, Michelle L., Hua, Yimin, Krainer, Adrian R., Andresen, Brage S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878440/
https://ncbi.nlm.nih.gov/pubmed/33300159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.24149
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg