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Transient ACE Inhibition Suppresses Future Fibrogenic Capacity and Heterogeneity of Cardiac Fibroblast Subpopulations

Transient angiotensin-converting enzyme (ACE) inhibition in spontaneously hypertensive rats (SHR) is known to protect against future injury-induced cardiac inflammation, fibrosis, and dysfunction; however, the mechanisms of protection have not been delineated. Here, we used single cell RNA sequencin...

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Detalhes bibliográficos
Publicado no:Hypertension
Main Authors: Garvin, Alexandra M, De Both, Matthew D, Talboom, Joshua S, Lindsey, Merry L, Huentelman, Matthew J, Hale, Taben M
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878436/
https://ncbi.nlm.nih.gov/pubmed/33486989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.120.16352
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