Epineural optogenetic activation of nociceptors initiates and amplifies inflammation

Activation of nociceptor sensory neurons by noxious stimuli both triggers pain and increases capillary permeability and blood flow to produce neurogenic inflammation(1,2), but whether nociceptors also interact with the immune system remains poorly understood. Here we report a neurotechnology for sel...

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Pubblicato in:Nat Biotechnol
Autori principali: Michoud, Frédéric, Seehus, Corey, Schönle, Philipp, Brun, Noé, Taub, Daniel, Zhang, Zihe, Jain, Aakanksha, Furfaro, Ivan, Akouissi, Outman, Moon, Rachel, Meier, Pascale, Galan, Katia, Doyle, Benjamin, Tetreault, Michael, Talbot, Sébastien, Browne, Liam E., Huang, Qiuting, Woolf, Clifford J., Lacour, Stéphanie P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878280/
https://ncbi.nlm.nih.gov/pubmed/32958958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-0673-2
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