Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH

Macrophage-mediated inflammation is critical in the pathogenesis of non-alcoholic steatohepatitis (NASH). Here, we describe that, with high-fat, high-sucrose-diet feeding, mature TIM4(pos) Kupffer cells (KCs) decrease in number, while monocyte-derived Tim4(neg) macrophages accumulate. In concert, mo...

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Udgivet i:Cell Rep
Main Authors: Daemen, Sabine, Gainullina, Anastasiia, Kalugotla, Gowri, He, Li, Chan, Mandy M., Beals, Joseph W., Liss, Kim H., Klein, Samuel, Feldstein, Ariel E., Finck, Brian N., Artyomov, Maxim N., Schilling, Joel D.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877246/
https://ncbi.nlm.nih.gov/pubmed/33440159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108626
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