High activity and low toxicity of a novel CD71-targeting nanotherapeutic named The-0504 on preclinical models of several human aggressive tumors

BACKGROUND: Ferritin receptor (CD71) is an example of a very attractive cancer target, since it is highly expressed in virtually all tumor types, including metastatic loci. However, this target can be considered to be inaccessible to conventional target therapies, due to its presence in many healthy...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Falvo, Elisabetta, Damiani, Verena, Conti, Giamaica, Boschi, Federico, Messana, Katia, Giacomini, Patrizio, Milella, Michele, De Laurenzi, Vincenzo, Morea, Veronica, Sala, Gianluca, Fracasso, Giulio, Ceci, Pierpaolo
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877078/
https://ncbi.nlm.nih.gov/pubmed/33568214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-021-01851-8
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