High activity and low toxicity of a novel CD71-targeting nanotherapeutic named The-0504 on preclinical models of several human aggressive tumors

BACKGROUND: Ferritin receptor (CD71) is an example of a very attractive cancer target, since it is highly expressed in virtually all tumor types, including metastatic loci. However, this target can be considered to be inaccessible to conventional target therapies, due to its presence in many healthy...

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Veröffentlicht in:J Exp Clin Cancer Res
Hauptverfasser: Falvo, Elisabetta, Damiani, Verena, Conti, Giamaica, Boschi, Federico, Messana, Katia, Giacomini, Patrizio, Milella, Michele, De Laurenzi, Vincenzo, Morea, Veronica, Sala, Gianluca, Fracasso, Giulio, Ceci, Pierpaolo
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877078/
https://ncbi.nlm.nih.gov/pubmed/33568214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-021-01851-8
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