Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation

Caveolae are spherically shaped nanodomains of the plasma membrane, generated by cooperative assembly of caveolin and cavin proteins. Cavins are cytosolic peripheral membrane proteins with negatively charged intrinsically disordered regions that flank positively charged α-helical regions. Here, we s...

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Publicat a:Nat Commun
Autors principals: Tillu, Vikas A., Rae, James, Gao, Ya, Ariotti, Nicholas, Floetenmeyer, Matthias, Kovtun, Oleksiy, McMahon, Kerrie-Ann, Chaudhary, Natasha, Parton, Robert G., Collins, Brett M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875971/
https://ncbi.nlm.nih.gov/pubmed/33568658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21035-4
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