Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer

The lipogenic enzyme stearoyl CoA desaturase (SCD) plays a key role in tumor lipid metabolism and membrane architecture. SCD is often up-regulated and a therapeutic target in cancer. Here, we report the unexpected finding that median expression of SCD is low in glioblastoma relative to normal brain...

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Vydáno v:Sci Adv
Hlavní autoři: Oatman, Nicole, Dasgupta, Nupur, Arora, Priyanka, Choi, Kwangmin, Gawali, Mruniya V., Gupta, Nishtha, Parameswaran, Sreeja, Salomone, Joseph, Reisz, Julie A., Lawler, Sean, Furnari, Frank, Brennan, Cameron, Wu, Jianqiang, Sallans, Larry, Gudelsky, Gary, Desai, Pankaj, Gebelein, Brian, Weirauch, Matthew T., D’Alessandro, Angelo, Komurov, Kakajan, Dasgupta, Biplab
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2021
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875532/
https://ncbi.nlm.nih.gov/pubmed/33568479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd7459
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