Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer

The lipogenic enzyme stearoyl CoA desaturase (SCD) plays a key role in tumor lipid metabolism and membrane architecture. SCD is often up-regulated and a therapeutic target in cancer. Here, we report the unexpected finding that median expression of SCD is low in glioblastoma relative to normal brain...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Oatman, Nicole, Dasgupta, Nupur, Arora, Priyanka, Choi, Kwangmin, Gawali, Mruniya V., Gupta, Nishtha, Parameswaran, Sreeja, Salomone, Joseph, Reisz, Julie A., Lawler, Sean, Furnari, Frank, Brennan, Cameron, Wu, Jianqiang, Sallans, Larry, Gudelsky, Gary, Desai, Pankaj, Gebelein, Brian, Weirauch, Matthew T., D’Alessandro, Angelo, Komurov, Kakajan, Dasgupta, Biplab
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875532/
https://ncbi.nlm.nih.gov/pubmed/33568479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd7459
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