TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload

BACKGROUND & AIMS: As the composition of the bile acid (BA) pool has a major impact on liver pathophysiology, we studied its regulation by the BA receptor Takeda G protein coupled receptor (TGR5), which promotes hepatoprotection against BA overload. METHODS: Wild-type, total and hepatocyte-speci...

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Publicat a:JHEP Rep
Autors principals: Bidault-Jourdainne, Valeska, Merlen, Grégory, Glénisson, Mathilde, Doignon, Isabelle, Garcin, Isabelle, Péan, Noémie, Boisgard, Raphael, Ursic-Bedoya, José, Serino, Matteo, Ullmer, Christoph, Humbert, Lydie, Abdelrafee, Ahmed, Golse, Nicolas, Vibert, Eric, Duclos-Vallée, Jean-Charles, Rainteau, Dominique, Tordjmann, Thierry
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7872982/
https://ncbi.nlm.nih.gov/pubmed/33604531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhepr.2020.100214
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