siRNA Knockdown of REDD1 Facilitates Aspirin-Mediated Dephosphorylation of mTORC1 Target 4E-BP1 in MDA-MB-468 Human Breast Cancer Cell Line

BACKGROUND: Mutations within genes encoding components of the PI3K/AKT/mTOR (phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin) signaling axis frequently activate the pathway in breast cancer, making it an attractive therapeutic target. Inhibition of mTORC1 (mechanistic targ...

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Detaylı Bibliyografya
Yayımlandı:Cancer Manag Res
Asıl Yazarlar: Savukaitytė, Aistė, Gudoitytė, Greta, Bartnykaitė, Agnė, Ugenskienė, Rasa, Juozaitytė, Elona
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Dove 2021
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7872862/
https://ncbi.nlm.nih.gov/pubmed/33574709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S264414
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