Effects of individual base-pairs on in vivo target search and destruction kinetics of bacterial small RNA

Base-pairing interactions mediate many intermolecular target recognition events. Even a single base-pair mismatch can cause a substantial difference in activity but how such changes influence the target search kinetics in vivo is unknown. Here, we use high-throughput sequencing and quantitative supe...

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Publicado no:Nat Commun
Main Authors: Poddar, Anustup, Azam, Muhammad S., Kayikcioglu, Tunc, Bobrovskyy, Maksym, Zhang, Jichuan, Ma, Xiangqian, Labhsetwar, Piyush, Fei, Jingyi, Singh, Digvijay, Luthey-Schulten, Zaida, Vanderpool, Carin K., Ha, Taekjip
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7870926/
https://ncbi.nlm.nih.gov/pubmed/33558533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21144-0
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