Structural basis for the biosynthesis of lovastatin

Statins are effective cholesterol-lowering drugs. Lovastatin, one of the precursors of statins, is formed from dihydromonacolin L (DML), which is synthesized by lovastatin nonaketide synthase (LovB), with the assistance of a separate trans-acting enoyl reductase (LovC). A full DML synthesis comprise...

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Publicat a:Nat Commun
Autors principals: Wang, Jialiang, Liang, Jingdan, Chen, Lu, Zhang, Wei, Kong, Liangliang, Peng, Chao, Su, Chen, Tang, Yi, Deng, Zixin, Wang, Zhijun
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7870829/
https://ncbi.nlm.nih.gov/pubmed/33558520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21174-8
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