The disordered Spindly C-terminus interacts with RZZ subunits ROD-1 and ZWL-1 in the kinetochore through the same sites in C. elegans

Spindly is a dynein adaptor involved in chromosomal segregation during cell division. While Spindly’s N-terminal domain binds to the microtubule motor dynein and its activator dynactin, the C-terminal domain (Spindly-C) binds its cargo, the ROD/ZW10/ZWILCH (RZZ) complex in the outermost layer of the...

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Bibliografske podrobnosti
izdano v:J Mol Biol
Main Authors: Henen, Morkos A., Myers, Walter, Schmitt, Lauren R., Wade, Kristen J., Born, Alexandra, Nichols, Parker J., Vögeli, Beat
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7870574/
https://ncbi.nlm.nih.gov/pubmed/33450249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2021.166812
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