Acquired Secondary RAS Mutation in BRAF(V600E)-Mutated Thyroid Cancer Patients Treated with BRAF Inhibitors

Background: The BRAF(V600E) mutation is the most common driver mutation in papillary thyroid cancer (PTC) and anaplastic thyroid cancer (ATC). This mutation is considered actionable and, for BRAF(V600E)-mutated ATC, a BRAF inhibitor (dabrafenib) in combination with an MEK inhibitor (trametinib) is F...

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Bibliografske podrobnosti
izdano v:Thyroid
Main Authors: Cabanillas, Maria E., Dadu, Ramona, Iyer, Pryianka, Wanland, Kacey B., Busaidy, Naifa L., Ying, Anita, Gule-Monroe, Maria, Wang, Jennifer R., Zafereo, Mark, Hofmann, Marie-Claude
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc., publishers 2020
Teme:
Thyroid Cancer and Nodules
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7869871/
https://ncbi.nlm.nih.gov/pubmed/32216548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2019.0514
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