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Acid-Catalyzed Hydrothiolation of gem-Difluorostyrenes to Access α,α–Difluoroalkylthioethers

The substitution of hydrogen atoms with fluorine in bioactive molecules can greatly impact physicochemical, pharmacokinetic, and pharmacodynamic properties. However, current synthetic methods cannot readily access many fluorinated motifs, which impedes utilization of these groups. Thus, the developm...

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Bibliografiske detaljer
Udgivet i:J Org Chem
Main Authors: Sorrentino, Jacob P., Orsi, Douglas L., Altman, Ryan A.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7869866/
https://ncbi.nlm.nih.gov/pubmed/33471529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.0c02440
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