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Impact of dimerization and N3 binding on molecular dynamics of SARS-CoV and SARS-CoV-2 main proteases

SARS-CoV-2 main protease is one of the major targets in drug development efforts against Covid-19. Even though several structures were reported to date, its dynamics is not understood well. In particular, impact of dimerization and ligand binding on the dynamics is an important issue to investigate....

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Detalles Bibliográficos
Publicado en:J Biomol Struct Dyn
Autores principales: Tekpinar, Mustafa, Yildirim, Ahmet
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7869440/
https://ncbi.nlm.nih.gov/pubmed/33525993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/07391102.2021.1880481
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