Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin

The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means of adherence and invasion. Heparin, a widely used a...

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Bibliografski detalji
Izdano u:Thromb Haemost
Glavni autori: Mycroft-West, Courtney J., Su, Dunhao, Pagani, Isabel, Rudd, Timothy R., Elli, Stefano, Gandhi, Neha S., Guimond, Scott E., Miller, Gavin J., Meneghetti, Maria C. Z., Nader, Helena B., Li, Yong, Nunes, Quentin M., Procter, Patricia, Mancini, Nicasio, Clementi, Massimo, Bisio, Antonella, Forsyth, Nicholas R., Ferro, Vito, Turnbull, Jeremy E., Guerrini, Marco, Fernig, David G., Vicenzi, Elisa, Yates, Edwin A., Lima, Marcelo A., Skidmore, Mark A.
Format: Artigo
Jezik:Inglês
Izdano: Georg Thieme Verlag KG 2020
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7869224/
https://ncbi.nlm.nih.gov/pubmed/33368089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0040-1721319
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