Engineering highly efficient backsplicing and translation of synthetic circRNAs

Circular RNAs (circRNAs) are highly stable RNA molecules that are attractive templates for expression of therapeutic proteins and non-coding RNAs. In eukaryotes, circRNAs are primarily generated by the spliceosome through backsplicing. Here, we interrogate different molecular elements including intr...

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Dettagli Bibliografici
Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Meganck, Rita M., Liu, Jiacheng, Hale, Andrew E., Simon, Katherine E., Fanous, Marco M., Vincent, Heather A., Wilusz, Jeremy E., Moorman, Nathaniel J., Marzluff, William F., Asokan, Aravind
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2021
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7868716/
https://ncbi.nlm.nih.gov/pubmed/33614232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2021.01.003
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