ADAMTS16 activates latent TGF-β, accentuating fibrosis and dysfunction of the pressure-overloaded heart

AIMS: Cardiac fibrosis is a major cause of heart failure (HF), and mediated by the differentiation of cardiac fibroblasts into myofibroblasts. However, limited tools are available to block cardiac fibrosis. ADAMTS16 is a member of the ADAMTS superfamily of extracellular protease enzymes involved in...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cardiovasc Res
Päätekijät: Yao, Yufeng, Hu, Changqing, Song, Qixue, Li, Yong, Da, Xingwen, Yu, Yubin, Li, Hui, Clark, Ian M, Chen, Qiuyun, Wang, Qing K
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2019
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Original Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7868664/
https://ncbi.nlm.nih.gov/pubmed/31297506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvz187
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