The Origin of Tumor DNA in Urine of Urogenital Cancer Patients: Local Shedding and Transrenal Excretion

SIMPLE SUMMARY: There is a clinical need for non-invasive methods to detect urogenital cancer, for which urine offers a promising liquid biopsy. Tumor DNA in urine originates from shedding of the local tumor, but may also be excreted transrenally as circulating DNA fragments from the bloodstream. To...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Hentschel, Anouk E., van den Helder, Rianne, van Trommel, Nienke E., van Splunter, Annina P., van Boerdonk, Robert A. A., van Gent, Mignon D. J. M., Nieuwenhuijzen, Jakko A., Steenbergen, Renske D. M.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7866784/
https://ncbi.nlm.nih.gov/pubmed/33572525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13030535
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