Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK

BACKGROUND: The PI 3-kinase (PI3K) pathway has been implicated as a target for melanoma therapy. METHODS: Given the high degree of genetic heterogeneity in melanoma, we sought to understand the breadth of variation in PI3K signalling in the large NZM panel of early passage cell lines developed from...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Tran, Khanh B., Kolekar, Sharada, Jabed, Anower, Jaynes, Patrick, Shih, Jen-Hsing, Wang, Qian, Flanagan, Jack U., Rewcastle, Gordon W., Baguley, Bruce C., Shepherd, Peter R.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7866738/
https://ncbi.nlm.nih.gov/pubmed/33549048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-021-07826-4
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