Intestinal SIRT1 Deficiency-Related Intestinal Inflammation and Dysbiosis Aggravate TNFα-Mediated Renal Dysfunction in Cirrhotic Ascitic Mice

In advanced cirrhosis, the TNFα-mediated intestinal inflammation and bacteria dysbiosis are involved in the development of inflammation and vasoconstriction-related renal dysfunction. In colitis and acute kidney injury models, activation of SIRT1 attenuates the TNFα-mediated intestinal and renal abn...

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Pubblicato in:Int J Mol Sci
Autori principali: Chou, Yu-Te, Liu, Tze-Tze, Yang, Ueng-Cheng, Huang, Chia-Chang, Liu, Chih-Wei, Huang, Shiang-Fen, Li, Tzu-Hao, Liu, Hsuan-Miao, Lin, Ming-Wei, Yang, Ying-Ying, Lee, Tzung-Yan, Huang, Yi-Hsiang, Hou, Ming-Chih, Lin, Han-Chieh
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7865325/
https://ncbi.nlm.nih.gov/pubmed/33513830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22031233
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