ZFP57 dictates allelic expression switch of target imprinted genes

ZFP57 is a master regulator of genomic imprinting. It has both maternal and zygotic functions that are partially redundant in maintaining DNA methylation at some imprinting control regions (ICRs). In this study, we found that DNA methylation was lost at most known ICRs in Zfp57 mutant embryos. Furth...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Jiang, Weijun, Shi, Jiajia, Zhao, Jingjie, Wang, Qiu, Cong, Dan, Chen, Fenghua, Zhang, Yu, Liu, Yuhan, Zhao, Junzheng, Chen, Qian, Gu, Linhao, Zhou, Wenjia, Wang, Chenhang, Fang, Zhaoyuan, Geng, Shuhui, Xie, Wei, Chen, Luo-Nan, Yang, Yang, Bai, Yun, Lin, Haodong, Li, Xiajun
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7865185/
https://ncbi.nlm.nih.gov/pubmed/33500348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005377118
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