Adenosine A(2A) receptor inhibition reduces synaptic and cognitive hippocampal alterations in Fmr1 KO mice

In fragile X syndrome (FXS) the lack of the fragile X mental retardation protein (FMRP) leads to exacerbated signaling through the metabotropic glutamate receptors 5 (mGlu5Rs). The adenosine A(2A) receptors (A(2A)Rs), modulators of neuronal damage, could play a role in FXS. A synaptic colocalization...

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Gepubliceerd in:Transl Psychiatry
Hoofdauteurs: Ferrante, Antonella, Boussadia, Zaira, Borreca, Antonella, Mallozzi, Cinzia, Pedini, Giorgia, Pacini, Laura, Pezzola, Antonella, Armida, Monica, Vincenzi, Fabrizio, Varani, Katia, Bagni, Claudia, Popoli, Patrizia, Martire, Alberto
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864914/
https://ncbi.nlm.nih.gov/pubmed/33547274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-021-01238-5
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