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Age-dependent anticonvulsant actions of perampanel and brivaracetam in the methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) model of seizures in developing rats

BACKGROUND: The antiseizure drugs commonly used as first- and second-line treatments for neonatal seizures display poor efficacy. Thus, drug mechanisms of action that differ from these typical agents might provide better seizure control. Perampanel, an AMPA-receptor antagonist, and brivaracetam, a S...

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Publicat a:Pharmacol Rep
Autors principals: CULJAT, Marko, HUIZENGA, Megan N., FORCELLI, Patrick A.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864869/
https://ncbi.nlm.nih.gov/pubmed/33210244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s43440-020-00189-w
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