A combinational chemo-immune therapy using an enzyme-sensitive nanoplatform for dual-drug delivery to specific sites by cascade targeting

Nanoparticle-based drug delivery faces challenges from the imprecise targeted delivery and the low bioavailability of drugs due to complex biological barriers. Here, we designed cascade-targeting, dual drug–loaded, core-shell nanoparticles (DLTPT) consisting of CD44-targeting hyaluronic acid shells...

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Bibliografiske detaljer
Udgivet i:Sci Adv
Main Authors: He, Yanmei, Lei, Lei, Cao, Jun, Yang, Xiaotong, Cai, Shengsheng, Tong, Fan, Huang, Dennis, Mei, Heng, Luo, Kui, Gao, Huile, He, Bin, Peppas, Nicholas A.
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2021
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864565/
https://ncbi.nlm.nih.gov/pubmed/33547067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba0776
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