Impact of TP53 mutation variant allele frequency on phenotype and outcomes in myelodysplastic syndromes

Although next-generation sequencing has allowed for the detection of somatic mutations in myelodysplastic syndromes (MDS), the clinical relevance of variant allele frequency (VAF) for the majority of mutations is unknown. We profiled TP53 and 20 additional genes in our training set of 219 patients w...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Sallman, DA, Komrokji, R, Vaupel, C, Cluzeau, T, Geyer, SM, McGraw, KL, Ali, NH Al, Lancet, J, McGinniss, MJ, Nahas, S, Smith, AE, Kulasekararaj, A, Mufti, G, List, A, Hall, J, Padron, E
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864381/
https://ncbi.nlm.nih.gov/pubmed/26514544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.304
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