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A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins
The origin recognition complex (ORC), composed of six subunits, ORC1–6, binds to origins of replication as a ring-shaped heterohexameric ATPase that is believed to be essential to recruit and load MCM2–7, the minichromosome maintenance protein complex, around DNA and initiate DNA replication. We pre...
Shranjeno v:
| izdano v: | J Biol Chem |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7863895/ https://ncbi.nlm.nih.gov/pubmed/32989049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015450 |
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