Early Long-Term Memory Impairment and Changes in the Expression of Synaptic Plasticity-Associated Genes, in the McGill-R-Thy1-APP Rat Model of Alzheimer's-Like Brain Amyloidosis

Accruing evidence supports the hypothesis that memory deficits in early Alzheimer Disease (AD) might be due to synaptic failure caused by accumulation of intracellular amyloid beta (Aβ) oligomers, then secreted to the extracellular media. Transgenic mouse AD models provide valuable information on AD...

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Detalles Bibliográficos
Publicado en:Front Aging Neurosci
Main Authors: Habif, Martín, Do Carmo, Sonia, Báez, María Verónica, Colettis, Natalia Claudia, Cercato, Magalí Cecilia, Salas, Daniela Alejandra, Acutain, María Florencia, Sister, Caterina Laura, Berkowicz, Valeria Laura, Canal, María Pilar, González Garello, Tomás, Cuello, A. Claudio, Jerusalinsky, Diana Alicia
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021
Assuntos:
Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862771/
https://ncbi.nlm.nih.gov/pubmed/33551786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.585873
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