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Heat stress induced arginylation of HuR promotes alternative polyadenylation of Hsp70.3 by regulating HuR stability and RNA binding

Arginylation was previously found to promote stabilization of heat shock protein 70.3 (Hsp70.3) mRNA and cell survival in mouse embryonic fibroblasts (MEFs) on exposure to heat stress (HS). In search of a factor responsible for these phenomena, the current study identified human antigen R (HuR) as a...

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Библиографические подробности
Опубликовано в: :Cell Death Differ
Главные авторы: Deka, Kamalakshi, Saha, Sougata
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862641/
https://ncbi.nlm.nih.gov/pubmed/32929216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00619-5
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