Comprehensive characterization and quantification of adeno associated vectors by size exclusion chromatography and multi angle light scattering

Adeno associated virus (AAV) capsids are a leading modality for in vivo gene delivery. Complete and precise characterization of capsid particles, including capsid and vector genome concentration, is necessary to safely and efficaciously dose patients. Size exclusion chromatography (SEC) coupled to m...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: McIntosh, Nicole L., Berguig, Geoffrey Y., Karim, Omair A., Cortesio, Christa L., De Angelis, Rolando, Khan, Ayesha A., Gold, Daniel, Maga, John A., Bhat, Vikas S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2021
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862616/
https://ncbi.nlm.nih.gov/pubmed/33542328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-82599-1
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