Adrenomedullin for steroid-resistant ulcerative colitis: a randomized, double-blind, placebo-controlled phase-2a clinical trial

BACKGROUND: Adrenomedullin (AM) is a bioactive peptide having many pleiotropic effects, including mucosal healing and immunomodulation. AM has shown beneficial effects in rodent models and in preliminary study for patients with ulcerative colitis (UC). We performed a clinical trial to investigate th...

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Detalhes bibliográficos
Publicado no:J Gastroenterol
Main Authors: Kita, Toshihiro, Ashizuka, Sinya, Ohmiya, Naoki, Yamamoto, Takayuki, Kanai, Takanori, Motoya, Satoshi, Hirai, Fumihito, Nakase, Hiroshi, Moriyama, Tomohiko, Nakamura, Masanao, Suzuki, Yasuo, Kanmura, Shuji, Kobayashi, Taku, Ohi, Hidehisa, Nozaki, Ryoichi, Mitsuyama, Keiichi, Yamamoto, Shojiro, Inatsu, Haruhiko, Watanabe, Koji, Hibi, Toshifumi, Kitamura, Kazuo
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Singapore 2020
Assuntos:
Original Article—Alimentary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862507/
https://ncbi.nlm.nih.gov/pubmed/33140199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00535-020-01741-4
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