Acute exercise impacts AhR and PD-1 levels of CD8(+) T-cells—Exploratory results from a randomized cross-over trial comparing endurance versus resistance exercise

PURPOSE: The programmed cell death protein 1 (PD-1) has become a promising target in cancer immunotherapy. PD-1 expression of CD8(+) T-cells may be increased via the exploitation of aryl hydrocarbon receptor (AhR) signaling with kynurenine (KYN) as a ligand. Since exercise affects KYN metabolism, we...

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Опубликовано в: :Eur J Appl Physiol
Главные авторы: Schenk, Alexander, Joisten, Niklas, Walzik, David, Koliamitra, Christina, Schoser, Daria, Bloch, Wilhelm, Zimmer, Philipp
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Berlin Heidelberg 2020
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862188/
https://ncbi.nlm.nih.gov/pubmed/33211154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00421-020-04552-w
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